Cambridge University Botanic Garden has lost its "Newton's apple tree" to Storm Eunice, reports BBC.
Garden curator Dr Samuel Brockington said the tree was planted in 1954 and had stood at the Brookside entrance of the botanic garden for 68 years.
The botanic garden said it had a clone of the tree that would be planted elsewhere in the garden soon.
The original tree from which an apple fell, leading Newton to devise his theory of gravity, is at Woolsthorpe Manor in Grantham, Lincolnshire.
Even though it was blown over in a gale in the 19th Century, the tree survived and over the years has been propagated by grafting, which involves binding one of the shoots on to another sapling.
Dr Brockington said analysis showed three trees in Cambridge, including the one at the botanic garden, was a clone of Newton's original apple tree.
He said even though it was a "sad loss" that it had fallen in Friday's storm, they were aware it was "on its way out" due to honey fungus.