Argentina took their unbeaten run to 25 matches and moved a step closer to qualifying for the World Cup with a hard-fought 1-0 win over Peru on Thursday.
Lautaro Martinez scored the only goal of the game two minutes before the break with a powerful header while Yoshimar Yotun missed a second half penalty for Peru.
Neymar and Gabriel Barbosa scored the other goals while Luis Suarez notched Uruguay's consolation.
Brazil top the single South American qualifying group by six points from Argentina, who have a nine point gap to those that could deny them a berth at Qatar 2022.
Argentina last lost in the 2019 Copa America semi-finals -- 2-0 against Brazil.
Since then the South American giants have been unstoppable, beating Brazil twice on their run, including earlier this year in the 2021 Copa America final.
Colombia and Ecuador played out a fractious ill-tempered 0-0 draw in Barranquilla that did little to boost either side's qualification hopes as they battle for a top four finish.
A brace from Edgar Pulgar and one from English-born Ben Brereton gave Chile a 3-0 win over rock-bottom Venezuela.