The England and Wales Cricket Board announced on Thursday that chairman Ian Watmore was stepping down with immediate effect, following criticism of the decision to cancel a tour of Pakistan.
Watmore, 63, has a reached a "mutual agreement" with the board to leave his role following the end of the domestic season after just over a year in the role.
"It is with regret that I step down as chair of the ECB, but I do so in mindfulness of my own wellbeing and that of the game which I love," said Watmore.
"Given this, the board and I feel the ECB will be better served by a new chair to take it forward post pandemic."
Watmore, formerly the chief executive of the Football Association, started his role as ECB chairman in September 2020 after the retirement of Colin Graves.
The ECB last month cancelled white-ball tours to Pakistan by the men's and women's teams due to take place this month, citing "increasing concerns about travelling to the region" and player welfare.
It came just days after New Zealand also pulled out of a tour to the country over security concerns.