West Indies captain Rovman Powell won the toss and chose to bat first in the third T20 against India in Guyana on Tuesday.
West Indies have a 2-0 lead in the five-match series after edging the opener by four runs followed by Sunday's dramatic two-wicket win.
"Jason Holder picked up a niggle in his knee, the medical staff suggested he get a break," said Powell.
He added: "The guys are very excited. We are on the doorsteps of victory. The guys are very optimistic. Hopefully things go well."
India made two changes, handing a debut to Yashasvi Jaiswal, who replaces Ishan Kishan, with Kuldeep Yadav coming in for Ravi Bishnoi.
India captain Hardik Pandya said after the toss: "We were looking to bat. We have some plans to keep things simple to him (West Indies' Nicholas Pooran, who scored a brilliant 67 on Sunday).
"Hope he misses and mistimes one and gets out. We'll try to keep things simple."
The tourists won the preceding two-Test series 1-0 before beating the West Indies 2-1 in the ODIs.
West Indies: Brandon King, Kyle Mayers, Johnson Charles, Nicholas Pooran (wkt), Rovman Powell (capt), Shimron Hetmyer, Romario Shepherd, Roston Chase, Akeal Hosein, Alzarri Joseph, Obed McCoy
India: Yashasvi Jaiswal, Shubman Gill, Suryakumar Yadav, Tilak Varma, Hardik Pandya (capt), Sanju Samson (wkt), Axar Patel, Arshdeep Singh, Yuzvendra Chahal, Mukesh Kumar, Kuldeep Yadav