Republicans have secured the 218 seats needed for a majority in the lower chamber of Congress a week after the midterm elections, the BBC's US partner CBS News projects.
While the party's margin in the House of Representatives is razor-thin, it is enough to stall President Joe Biden's agenda for the next two years.
A handful of seats remain to be called.
The Republicans - who had hoped to win back control of both chambers - underperformed expectations in last week's midterms.
They won the seat they needed for their House majority on Wednesday when California's 27th district went to incumbent Mike Garcia.
The Republican party is now projected to win between 218-223 seats in the 435-seat House, according to CBS.
But with votes in cliff-hanger races still being tallied, their majority may not be clear for days or even weeks.
"Americans are ready for a new direction, and House Republicans are ready to deliver," the California congressman tweeted on Wednesday night.
In order to be elected Speaker, the House Republican minority leader must work to receive majority support from the 435 members of the full House.
Nancy Pelosi was able to accomplish a considerable amount with just a nine-seat margin, but she has proven to be singularly gifted at wrangling recalcitrant Democrats. There's no guarantee Republicans, who run the gamut from moderates in suburban battleground districts to Freedom Caucus conservative hard-liners, will be equally co-operative with their party's leadership.
A majority is a majority, however, and assuming Republicans can pull together to elect a speaker when the full chamber votes in January, they will reap the rewards of their midterm victory. House rules give the party in charge control over which legislation gets votes and which languishes in limbo. Republicans will also run all the House committees, with their sweeping oversight and subpoena powers.
While the fractious Republican caucus may not agree on much, they will be able to stop Joe Biden's agenda in its tracks and force showdowns over federal budget priorities.
For a party that has watched Democrats rack up a string of legislative successes over the past two years, that by itself will be a significant achievement.
President Joe Biden congratulated Mr McCarthy and offered to work with Republicans to deliver results for Americans.
"As I said last week, the future is too promising to be trapped in political warfare," said the Democratic president.
"The American people want us to get things done for them. They want us to focus on the issues that matter to them and on making their lives better."
Republicans had hoped that Mr Biden's relatively low popularity, stubborn inflation, and the fact that congressional maps were redrawn by Republican-led state legislatures would add up to midterms victories for them.
The blame for last Tuesday's lacklustre showing has largely landed on two party leaders: former President Donald Trump and Senate minority leader Mitch McConnell.
On Tuesday night, the ex-president formally announced a third bid for the White House in 2024 from a ballroom at his Mar-a-Lago estate in Florida.
In Washington on Wednesday, Mr McConnell was re-elected as Senate minority leader, fending off a challenge from fellow Republican Rick Scott of Florida.
This was the first challenge to his lengthy leadership tenure in 15 years.
Non-congressional results are still trickling in more than a week after election day.
On Wednesday, congresswoman Karen Bass was projected to win the race to be the next mayor of Los Angeles, the second largest city in America, after defeating billionaire businessman Rick Caruso.
The Democrat will become the first woman to hold the office and the city's second ever black mayor.