India skipper Shikhar Dhawan won the toss and elected to field against South Africa in Tuesday's third and deciding one-day international after a brief wet outfield delay.
The hosts, who bounced back from their opening loss to level the series at 1-1, are unchanged for the final match in New Delhi.
David Miller makes his debut as South Africa captain after Keshav Maharaj, who stood in for Temba Bavuma in the second ODI, was ruled out sick.
The Proteas, who are looking for crucial Super League points for a direct entry into next year's 50-overs World Cup in India, have made three changes.
Marco Jansen, Andile Phehlukwayo and Lungi Ngidi make the team in place of Kagiso Rabada, Bavuma and Tabraiz Shamsi.
"It is always a privilege to be the skipper," said Miller.
"We would have bowled first. (A) few guys have fallen sick. Maharaj fell sick. Shamsi and Bavuma are down as well."
India: Shikhar Dhawan (capt), Shubman Gill, Ishan Kishan, Shreyas Iyer, Sanju Samson (wk), Washington Sundar, Shahbaz Ahmed, Shardul Thakur, Kuldeep Yadav, Mohammed Siraj, Avesh Khan
South Africa: Quinton de Kock (wk), Janneman Malan, Reeza Hendricks, Aiden Markram, Heinrich Klaasen, David Miller (capt), Marco Jansen, Andile Phehlukwayo, Bjorn Fortuin, Lungi Ngidi, Anrich Nortje
Umpires: Anil Chaudhary (IND), Jayaraman Madanagopal (IND)
TV Umpire: Virender Sharma (IND)
Match Referee: Javagal Srinath (IND)