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New strategy to develop an effective vaccine against HIV: Researchers

  • Sun Online Desk
  • 5th October, 2022 05:46:48 PM
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New strategy to develop an effective vaccine against HIV: Researchers

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Researchers have long studied how a small percentage of infected individuals with HIV are able to make bnAbs. However, researchers have demonstrated that bnAbs can protect against the virus if they are present before a person gets infected.

Researchers have come together to make critical advances in developing an effective vaccine against the human immunodeficiency virus (HIV).

The findings were published in the journal Immunity in two individual papers.

The research describes the first steps in a vaccine approach that aims to prompt the creation of broadly neutralizing antibodies (bnAbs)--antibodies that are broad enough to fight and protect against many different variants of a virus.

By identifying the most promising bnAbs and the human genes needed to make them--as well as designing protein and mRNA vaccine candidates to begin bnAb creation and verifying the vaccine candidates--the team is paving the way to create an effective HIV vaccine.

"Our two studies describe a collaborative effort to genetically and structurally understand bnAbs, and ultimately 'reverse engineer' vaccines to elicit these bnAbs," says senior author William Schief, PhD, a Scripps Research professor and executive director of vaccine design at IAVI's Neutralizing Antibody Center at Scripps Research.

Source: ANI