Rafael Nadal enjoyed a winning return after a six-week injury break, opening his Madrid campaign with a 6-1, 7-6(7/4) success over Serbia's Miomir Kecmanovic on Wednesday.
The Spanish star had been sidelined with a rib injury since his Indian Wells final defeat in March but showed little sign of rust as he skipped into the third round.
"Today I was able to play one hour, 55 minutes against an opponent that was playing really well in these last months, so a really good victory, a lot of value to it," said the 35-year-old Mallorcan.
"It helps me a lot to reach my final goal, which is to recover my previous health and previous fitness. I'm very excited about it."
The 22-year-old Kecmanovic entered the match carrying the second-highest tally of wins on tour this season -- his 23 victories placing him just one behind Andrey Rublev, Stefanos Tsitsipas and Carlos Alcaraz.
Nadal, a three-time title winner in 2022, improved to 21-1 for the year and now plays Belgian qualifier David Goffin.
After a fairly routine opening set and a brief rain delay, Nadal faced significant resistance from the world number 32, who was broken in game five of the second set but struck back immediately as he started to find his range from the baseline.
The pair were neck and neck, gifting each other mini-breaks before Nadal finally secured the win in just under two hours with an ace.
Second-seeded Alexander Zverev began his title defence with a hard-fought 4-6, 6-4, 6-4 win over former US Open champion Marin Cilic.
The German is a two-time Madrid champion and now owns a 16-2 win-loss record at the Caja Magica.
Fourth seed Tsitsipas beat French wildcard Lucas Pouille 6-3, 6-4, while Jannik Sinner and Felix Auger-Aliassime both won in straight sets.
British ninth seed Cameron Norrie edged past John Isner 6-4, 6-7 (5/7), 6-4 to advance to a last-16 clash with teenage star Alcaraz, but fifth seed Casper Ruud lost in three sets to Dusan Lajovic.
- Jabeur reaches semi-finals -
Earlier on centre court, Ons Jabeur marched into the women's semi-finals with a crushing 6-3, 6-2 win over former world number one Simona Halep.
After avenging her Charleston final defeat to Belinda Bencic in the previous round, the Tunisian world number 10 reversed her result against Halep from Dubai three months ago, sweeping the Romanian aside in just 67 minutes.
The first ever Arab tennis player to crack the top 10, Jabeur is through to the second WTA 1000 semi-final of her career where she faces Russian Ekaterina Alexandrova.
"Simona, it's never easy to play against her, she's a great champion, she was number one, a Grand Slam champion," said the 27-year-old Jabeur, who is now 2-2 against Halep in their head-to-head.
"I was more aggressive this time, physically much better on the court. My drop shot helped me a lot today. I'm very happy with the attitude today, so hopefully we'll continue with this level."
Halep drew first blood, inching ahead 2-1 but Jabeur scooped the next three games and sealed the set with a flashy point that ended with a forehand down-the-line winner.
Jabeur continued to pepper Halep with her signature drop shot, earning two breaks in the second set en route to a convincing victory.
Jessica Pegula, the 12th seed, eliminated Spain's Sara Sorribes Tormo 6-4, 6-2. Her next opponent is Jil Teichmann, the Swiss who defeated Ukraine's Anhelina Kalinina 6-3, 6-4.