Diogo Jota and Bernardo Silva have been named in Portugal's front three alongside captain Cristiano Ronaldo for the holders' opening match of Euro 2020 against Hungary in Budapest on Tuesday.
Coach Fernando Santos opted for Liverpool forward Jota and Manchester City's Silva ahead of Atletico Madrid star Joao Felix for the Group F game.Bruno Fernandes starts in midfield, with Wolverhampton Wanderers pair Joao Moutinho and Ruben Neves, along with Lille's Ligue 1 title-winner Renato Sanches, settling for places on the bench.
The 38-year-old Pepe got the nod to partner Ruben Dias at centre-back ahead of Jose Fonte, while Rui Patricio remains the number one with Anthony Lopes a substitute.
Hosts Hungary are without forward Dominik Szoboszlai after the RB Leipzig man was ruled out of the tournament through injury.
Adam Szalai, who has scored 23 international goals, leads the line.
The other Group F match later on Tuesday sees Germany take on world champions France in Munich.
Starting line-ups:Hungary (3-5-2)
Peter Gulacsi; Attila Szalai, Willi Orban, Endre Botka; Attila Fiola, Andras Schafer, Adam Nagy, Laszlo Kleinheisler, Gergo Lovrencsics; Roland Sallai, Adam Szalai (capt)
Coach: Marco Rossi (ITA)
Rui Patricio; Raphael Guerreiro, Pepe, Ruben Dias, Nelson Semedo; Bruno Fernandes, William Carvalho, Danilo; Bernardo Silva, Diogo Jota, Cristiano Ronaldo (capt)
Coach: Fernando Santos (POR)
Referee: Cuneyt Cakir (TUR)