Some 66,570 people in Brazil died of Covid-19 in March, more than double the previous monthly record, figures show.
The country's health service has been pushed to the brink as cases of the virus continue to climb.President Jair Bolsonaro has faced intense criticism for his handling of the crisis and was hit by high-profile resignations this week.
But on Wednesday he again railed against lockdown measures imposed by local governors and mayors.
"We had, and we have, two enemies - the virus and unemployment! It is a reality! We are not going to solve this problem by staying at home," he said.
Wednesday also saw a further 3,800 new deaths and over 90,000 new coronavirus cases. Brazil's daily deaths currently account for about a quarter of all coronavirus fatalities in the world.