CBS News said Tuesday that Charlie Rose's contract has been terminated.
An internal memo said the decision "followed the revelation yesterday of extremely disturbing and intolerable behavior."
CBS suspended Rose shortly after The Washington Post published a 5,000-word story on Monday about alleged harassment, based on interviews with eight women who described "unwanted sexual advances."
Rose said in a statement that he "deeply apologized" for what he admitted was "inappropriate behavior."
After the initial Post story came out, other women came forward with additional allegations of sexual misconduct. By Tuesday morning, CBS executives determined that it was impossible for him to return to "CBS This Morning," the daily broadcast he has co-hosted for the past five years.
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CBS did not immediately name a replacement for Rose on the program.
On Tuesday morning's show, co-hosts Norah O'Donnell and Gayle King addressed the matter in frank detail.
"Charlie does not get a pass here. He doesn't get a pass from anyone in this room," King said. "We are all deeply affected. We are all rocked by this."
"This will be investigated. This has to end. This behavior is wrong. Period," O'Donnell said.
It is unknown if the network is commissioning a formal investigation into who knew what about the misconduct allegations, and when they may have known it.
A CBS News spokeswoman did not immediately respond to a request for comment.
"CBS News has reported on extraordinary revelations at other media companies this year and last. Our credibility in that reporting requires credibility managing basic standards of behavior.
That is why we have taken these actions," CBS News president David Rhodes said in the internal memo.
He also commented that "no one may be able to correct the past," but "what may once have been accepted should not ever have been acceptable."
The full memo from CBS News president David Rhodes:
A short time ago we terminated Charlie Rose's employment with CBS News, effective immediately. This followed the revelation yesterday of extremely disturbing and intolerable behavior said to have revolved around his PBS program.
Despite Charlie's important journalistic contribution to our news division, there is absolutely nothing more important, in this or any organization, than ensuring a safe, professional workplace—a supportive environment where people feel they can do their best work. We need to be such a place.
I've often heard that things used to be different. And no one may be able to correct the past. But what may once have been accepted should not ever have been acceptable.
CBS News has reported on extraordinary revelations at other media companies this year and last. Our credibility in that reporting requires credibility managing basic standards of behavior. That is why we have taken these actions.
Let's please remember our obligations to each other as colleagues. We will have human resources support today and every day, and we are organizing more personal and direct training which you will hear about from senior management shortly.
I'm deeply disappointed and angry that people were victimized—and that even people not connected with these events could see their hard work undermined. If all of us commit to the best behavior and the best work -- that is what we can be known for.