Portugal have a fully-fit squad to choose from although Bruno Alves could be preferred to Jose Fonte in defence.
Sporting Lisbon winger Bruno Fernandes underwhelmed on his World Cup debut against Spain and may be replaced by Gelson Martins or Joao Mario.
Morocco have an injury crisis at right-back, with Nordin Amrabat ruled out with concussion following a clash of heads in the defeat to Iran.
Regular right-back Nabil Dirar remains sidelined with a knee injury.
Their only previous meeting came at the 1986 World Cup. Morocco's 3-1 victory was their first ever win in the tournament.
Portugal have not lost against a non-European nation at the World Cup since June 2002 (W5, D3), in a 1-0 defeat to South Korea.
Against Spain, Cristiano Ronaldo became just the fourth player to score in four World Cups, after Uwe Seeler, Pele and Miroslav Klose.
It was Ronaldo's 51st hat-trick and the 51st in World Cup history.
At 33 years and 130 days, it made Ronaldo the oldest scorer of a hat-trick in a World Cup.
Ronaldo's third goal drew him level with Ferenc Puskas as the second-highest scorer in the history of international football with 84 goals. Only Iran's Ali Daei (109) has scored more.
Before the opening match, Ronaldo had scored just three goals in 13 World Cup appearances.
Morocco had 68% possession in their 1-0 defeat to Iran, the most by a losing team in a World Cup match since June 2010, when Spain had 73% possession against Switzerland, but lost 1-0.
The Atlas Lions did not face a single shot in the second half of that game, but lost to a 95th minute own goal.
Aziz Bouhaddouz became just the third substitute to score an own-goal in a World Cup match. The others are Hungary's Laszlo Dajka in 1986 (against USSR) and Portugal's Petit in 2006 (versus Germany).