Alex Iwobi’s goal saw Nigeria become the first African team to qualify for next year’s World Cup in Russia, while Ghana were eliminated in the qualifiers.
A 73rd-minute strike by Arsenal forward Iwobi handed the Super Eagles a 1-0 success over Zambia in Uyo, ensuring top spot in Group B with a game to spare.
“It was my goal to qualify this team to an amazing tournament like the World Cup,” said Nigeria captain Mikel Obi.
Nigeria now have 13 points with second-placed Zambia on seven. Cameroon are on six points after defeating Algeria 2-0.
Ghana, quarter-finalists at the 2010 World Cup in South Africa, were eliminated after managing only a goalless draw in Uganda when needing a win to keep their slim hopes alive.