Chuck Berry, a music pioneer often called "the Father of Rock 'n' Roll," died Saturday at his home outside St. Louis, his verified Facebook page said. He was 90.
The singer was found unresponsive at lunchtime on Saturday, St Charles County police said.
Berry's seven-decade career boasted a string of hits, including classics Roll Over Beethoven and Johnny B. Goode.
He received a lifetime achievement Grammy in 1984 and was among the first inductees to the Rock and Roll Hall of Fame in 1986.
A post on the St. Charles County police Facebook page said officers responded to a medical emergency at the residence around 12:40 p.m. (1:40 p.m. ET) Saturday and found an unresponsive man inside. Resuscitation efforts failed.
"The St. Charles County Police Department sadly confirms the death of Charles Edward Anderson Berry Sr., better known as legendary musician Chuck Berry."
"Unfortunately, the 90-year-old man could not be revived and was pronounced deceased at 1:26pm," the statement continued.
High-profile musicians were quick to pay tribute to Berry's talent and influence.
Motown legends The Jacksons tweeted: "Chuck Berry merged blues & swing into the phenomenon of early rock'n'roll. In music, he cast one of the longest shadows. Thank You Chuck."
Singer-songwriter Huey Lewis described him as "maybe the most important figure in all of rock and roll".
"His music and influence will last forever," he added.
Beatles drummer Ringo Starr quoted one of Berry's own lyrics on Twitter, saying: "Just let me hear some of that rock 'n' roll music any old way you use it."